NUP58

Across TCGA patient cohorts, NUP58 mutation is significantly associated with the RNA expression of many other genes, with 3,386 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP58-associated genes across cancer lineages are RNU6-786P, LINC02559, and LINC00290. Each is linked with NUP58 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUP58-to-partner and partner-to-NUP58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-786P grouped by NUP58-low versus NUP58-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP58→partner) and Y-score (partner→NUP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-786P →	+0.377	+3.704	<.001	.001	3	3
CESC	LINC02559 →	+0.749	+4.020	<.001	.009	3	2
CESC	LINC00290 →	+0.098	+5.852	<.001	<.001	3	2
COAD	RNU6-709P →	+0.742	+6.142	<.001	<.001	3	2
SKCM	MIR3193 →	+0.618	+4.508	<.001	.001	3	2
UCEC	RNVU1-28 →	+0.477	+1.313	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,386 associations by consensus.

RNU6-786P by NUP58 expression — CESC

Explore this box plot interactively →