NUP58

Across TCGA patient cohorts, NUP58 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP58-associated genes across cancer lineages are p62 Lck ligand, PDCD4, and C-Raf. Each is linked with NUP58 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP58-to-partner and partner-to-NUP58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by NUP58-low versus NUP58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP58→partner) and Y-score (partner→NUP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.385	+3.807	<.001	<.001	3	2
UCEC	PDCD4 →	-0.481	-3.906	.002	<.001	3	2
UCEC	C-Raf →	+0.187	+2.169	<.001	.003	3	2
UCEC	Di-Ras3 →	-0.195	-2.986	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.081	-1.673	.017	.040	3	1
UCEC	EGFR_pY1068 →	-0.279	-2.137	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p62 Lck ligand by NUP58 expression — UCEC

Explore this box plot interactively →