NUP58

Across TCGA cell cohorts, NUP58 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,377 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NUP58-associated GO terms across cancer lineages are Positive regulation of mitotic sister chromatid separation, Regulation of mitotic spindle checkpoint, and Positive regulation of mitotic metaphase/anaphase transition. Each is linked with NUP58 in more than 16 cancer types. Because this analysis shows association rather than direction, both NUP58-to-partner and partner-to-NUP58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic sister chromatid separation grouped by NUP58-low versus NUP58-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP58→partner) and Y-score (partner→NUP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of mitotic sister chromatid separation →	+0.163	+0.964	<.001	<.001	3	17
BREAST	Regulation of mitotic spindle checkpoint →	+0.146	+0.974	<.001	<.001	3	17
PANCREAS	Positive regulation of mitotic metaphase/anaphase transition →	+0.144	+0.903	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Centriole replication →	+0.115	+1.373	<.001	<.001	3	17
BREAST	Regulation of mitotic cell cycle spindle assembly checkpoint →	+0.146	+0.974	<.001	<.001	3	17
PANCREAS	Negative regulation of cell cycle process →	+0.063	+0.799	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,377 associations by consensus.

Positive regulation of mitotic sister chromatid separation by NUP58 expression — PANCREAS

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