NUP43

Across TCGA pan-cancer cohorts, NUP43 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUP43 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUP43 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NUP43 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where NUP43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.761	0.462	<.001	55	view →
LUAD	OS	Tertile	All	0.960	0.772	.008	20	view →
CCRCC	OS	Median	III,IV	0.565	0.889	.002	16	view →
GBM	DFS	Tertile	All	0.483	0.332	.039	5	view →
UCEC	OS	Quartile	II,III,IV	0.558	1.000	.038	4	view →
PDAC	DFS	Quartile	II,III,IV	0.448	0.267	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUP43–HNSC (DFS)

Open the HNSC breakdown →