NUP43

Across TCGA patient cohorts, NUP43 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP43-associated genes across cancer lineages are STAT3_pY705, AR, and Bax. Each is linked with NUP43 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP43-to-partner and partner-to-NUP43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by NUP43-low versus NUP43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP43→partner) and Y-score (partner→NUP43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.450	-2.990	.001	.036	3	1
UCEC	AR →	-0.421	-3.169	.040	.020	3	1
UCEC	Bax →	+0.323	+2.817	.014	.036	3	1
UCEC	EGFR_pY1068 →	-0.342	-3.169	.013	.019	2	1
UCEC	ETS-1 →	+0.352	+3.169	.043	.020	1	2
UCEC	p62 Lck ligand →	+0.493	+3.169	.005	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

STAT3_pY705 by NUP43 expression — UCEC

Explore this box plot interactively →