NUP43

Across TCGA cell cohorts, NUP43 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,224 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUP43-associated GO terms across cancer lineages are Centrosome cycle, Regulation of mitotic sister chromatid separation, and Regulation of chromosome separation. Each is linked with NUP43 in more than 19 cancer types. Because this analysis shows association rather than direction, both NUP43-to-partner and partner-to-NUP43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome cycle grouped by NUP43-low versus NUP43-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP43→partner) and Y-score (partner→NUP43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Centrosome cycle →	+0.100	+1.469	<.001	<.001	3	20
URINARY_TRACT	Regulation of mitotic sister chromatid separation →	+0.147	+0.824	<.001	<.001	3	20
SKIN	Regulation of chromosome separation →	+0.146	+0.681	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.125	+1.125	.002	<.001	3	20
LUNG_NSCLC_LUSC	Centriole replication →	+0.113	+1.192	.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.130	+0.960	.001	.003	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,224 associations by consensus.

Centrosome cycle by NUP43 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →