NUP37

Across TCGA patient cohorts, NUP37 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP37-associated genes across cancer lineages are RNU6-1228P, ANKRD60, and MIR1227. Each is linked with NUP37 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP37-to-partner and partner-to-NUP37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1228P grouped by NUP37-low versus NUP37-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP37→partner) and Y-score (partner→NUP37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1228P →	+0.324	+4.191	<.001	.009	3	2
HNSC	ANKRD60 →	+0.165	+5.303	<.001	.006	3	1
HNSC	MIR1227 →	+0.450	+6.763	<.001	<.001	3	1
BLCA	MORF4L1P6 →	+0.159	+7.640	<.001	.009	3	1
UCEC	ESS2 →	+0.298	+3.010	.005	<.001	3	1
UCEC	SH3BP1 →	+0.527	+2.609	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

RNU6-1228P by NUP37 expression — LUSC

Explore this box plot interactively →