NUP35

Across TCGA cell cohorts, NUP35 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP35-associated genes across cancer lineages are OR14K1, PRND, and BPIFA1. Each is linked with NUP35 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP35-to-partner and partner-to-NUP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14K1 grouped by NUP35-low versus NUP35-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP35→partner) and Y-score (partner→NUP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR14K1 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PRND →	+0.022	+3.878	.007	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.134	+3.688	.001	.002	3	1
LARGE_INTESTINE	TAS2R41 →	+0.040	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR14K1 by NUP35 expression — LARGE_INTESTINE

Explore this box plot interactively →