NUP210

Across TCGA patient cohorts, NUP210 mutation is significantly associated with the RNA expression of many other genes, with 6,179 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP210-associated genes across cancer lineages are DONSON, MELK, and NCAPG. Each is linked with NUP210 in more than 4 cancer types. Because this analysis shows association rather than direction, both NUP210-to-partner and partner-to-NUP210 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DONSON grouped by NUP210-low versus NUP210-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP210→partner) and Y-score (partner→NUP210) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DONSON →	+0.293	+2.058	.004	<.001	3	5
UCEC	MELK →	+0.526	+2.765	<.001	<.001	3	5
UCEC	NCAPG →	+0.514	+1.847	<.001	<.001	3	5
UCEC	RPA2 →	+0.299	+1.637	.001	.004	3	5
COAD	ZWINT →	+0.511	+3.026	.001	<.001	3	5
SKCM	COQ3 →	+0.339	+1.141	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,179 associations by consensus.

DONSON by NUP210 expression — UCEC

Explore this box plot interactively →