NUP210

Across TCGA patient cohorts, NUP210 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP210-associated genes across cancer lineages are C-Raf, 4E-BP1_pT37_T46, and IRS1. Each is linked with NUP210 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUP210-to-partner and partner-to-NUP210 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by NUP210-low versus NUP210-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP210→partner) and Y-score (partner→NUP210) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.212	+3.493	<.001	.002	3	4
SKCM	4E-BP1_pT37_T46 →	-0.247	-1.362	.031	.032	3	4
LUAD	IRS1 →	+0.145	+2.832	.029	.034	3	3
UCEC	eEF2 →	+0.262	+2.247	.004	.001	3	3
UCEC	Annexin-1 →	+0.579	+1.836	<.001	<.001	3	3
UCEC	Rictor_pT1135 →	-0.055	-1.263	.036	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

C-Raf by NUP210 expression — COAD

Explore this box plot interactively →