NUP153

Across TCGA pan-cancer cohorts, NUP153 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUP153 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUP153 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUP153 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where NUP153 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.291	1.000	.001	47	view →
LSCC	DFS	Median	All	0.990	0.884	.008	32	view →
PDAC	OS	Median	III,IV	0.938	0.549	.011	9	view →
CCRCC	OS	Median	All	0.599	0.985	.010	6	view →
LUAD	DFS	Median	III,IV	0.697	0.316	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NUP153–HNSC (DFS)

Open the HNSC breakdown →