NUP153

Across TCGA patient cohorts, NUP153 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP153-associated genes across cancer lineages are eEF2, FOXO3a_pS318_S321, and GAPDH. Each is linked with NUP153 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUP153-to-partner and partner-to-NUP153 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by NUP153-low versus NUP153-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP153→partner) and Y-score (partner→NUP153) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.228	+1.906	.023	.014	3	4
UCEC	FOXO3a_pS318_S321 →	-0.094	-1.106	.007	.020	3	3
UCEC	GAPDH →	+0.297	+1.584	.049	.015	3	3
UCEC	eIF4E →	+0.173	+1.447	.003	.002	3	2
UCEC	A-Raf_pS299 →	-0.112	-1.736	<.001	.006	3	2
UCEC	ERK2 →	+0.180	+1.447	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by NUP153 expression — UCEC

Explore this box plot interactively →