NUMBL

Across TCGA pan-cancer cohorts, NUMBL Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NUMBL data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NUMBL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NUMBL expression acts as an unfavorable survival marker.

COAD, UCEC, and SCLC are the cancer types where NUMBL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.111	0.871	<.001	16	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SCLC	OS	Median	All	0.219	0.650	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NUMBL–COAD (OS)

Open the COAD breakdown →