NUMBL

Across TCGA pan-cancer cohorts, NUMBL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NUMBL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NUMBL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NUMBL is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRP, HNSC, and LUAD are the cancer types where NUMBL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUMBL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+1.336	<.001	11	view →
HNSC	Male	III,IV	+1.041	<.001	11	view →
LUAD	All	III,IV	+0.973	<.001	11	view →
KIRC	All	All	+0.467	<.001	9	view →
LIHC	All	II,III,IV	+0.620	<.001	8	view →
KICH	Female	All	−1.453	<.001	5	view →
LUSC	Male	II,III,IV	+0.986	<.001	5	view →
COAD	Female	All	+0.669	<.001	5	view →
CHOL	Male	All	+2.250	<.001	4	view →
UCEC	All	All	−0.693	<.001	4	view →
PRAD	All	All	−0.301	.006	2	view →
BLCA	Male	IV	−1.525	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NUMBL–KIRP

Open the KIRP breakdown →