NUMBL

Across TCGA pan-cancer cohorts, NUMBL mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUMBL data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUMBL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUMBL expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where NUMBL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.847	0.993	.001	84	view →
GBM	OS	Median	All	0.277	0.473	.003	11	view →
PDAC	OS	Median	III,IV	1.000	0.537	.008	11	view →
LUAD	DFS	Tertile	All	0.852	0.560	.025	7	view →
UCEC	OS	Median	II,III,IV	0.638	1.000	.014	4	view →
LSCC	OS	Median	II,III,IV	0.775	1.000	.021	3	view →
HNSC	DFS	Quartile	III,IV	0.691	0.386	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUMBL–CCRCC (DFS)

Open the CCRCC breakdown →