NUMBL

Across TCGA patient cohorts, NUMBL mutation is significantly associated with the RNA expression of many other genes, with 1,376 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUMBL-associated genes across cancer lineages are MIR375, GGCTP3, and SMR3B. Each is linked with NUMBL in more than 1 cancer types. Because this analysis shows association rather than direction, both NUMBL-to-partner and partner-to-NUMBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR375 grouped by NUMBL-low versus NUMBL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUMBL→partner) and Y-score (partner→NUMBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR375 →	+0.487	+4.484	<.001	.002	3	2
COAD	GGCTP3 →	+0.219	+4.037	.003	.004	3	2
SKCM	SMR3B →	+1.407	+4.328	<.001	<.001	3	2
SKCM	RNU6-290P →	+0.194	+4.469	<.001	.006	3	2
LGG	MIR526A2 →	+0.533	+7.977	<.001	.007	3	2
LGG	PRAMEF25 →	+0.049	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,376 associations by consensus.

MIR375 by NUMBL expression — COAD

Explore this box plot interactively →