NUMBL

Across TCGA patient cohorts, NUMBL mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUMBL-associated genes across cancer lineages are eIF4E, MSH6, and p62 Lck ligand. Each is linked with NUMBL in more than 1 cancer types. Because this analysis shows association rather than direction, both NUMBL-to-partner and partner-to-NUMBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NUMBL-low versus NUMBL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUMBL→partner) and Y-score (partner→NUMBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.226	+2.459	.026	.020	3	1
UCEC	MSH6 →	-0.416	-2.999	.009	.035	3	1
UCEC	p62 Lck ligand →	+0.377	+2.459	.016	.020	3	1
UCEC	VHL →	-1.045	-2.459	.001	.019	3	1
UCEC	Fibronectin →	-0.344	-2.990	.030	.036	2	1
UCEC	Annexin-1 →	+0.714	+3.019	.004	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

eIF4E by NUMBL expression — UCEC

Explore this box plot interactively →