NUMBL

Across TCGA cell cohorts, NUMBL mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUMBL-associated genes across cancer lineages are TAS2R8, OR10W1, and OR2D3. Each is linked with NUMBL in more than 1 cancer types. Because this analysis shows association rather than direction, both NUMBL-to-partner and partner-to-NUMBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R8 grouped by NUMBL-low versus NUMBL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUMBL→partner) and Y-score (partner→NUMBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAS2R8 →	+0.026	+3.189	.001	.002	3	2
LARGE_INTESTINE	OR10W1 →	+0.011	+3.977	<.001	.001	3	1
LARGE_INTESTINE	OR2D3 →	+0.022	+3.510	.001	.003	3	1
LARGE_INTESTINE	SPEM1 →	+0.094	+3.347	<.001	.005	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
BLOOD_Leukemia	NKX2-2 →	+0.377	+3.379	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TAS2R8 by NUMBL expression — BLOOD_Leukemia

Explore this box plot interactively →