NUMB

Across TCGA pan-cancer cohorts, NUMB Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NUMB data layer compared with 21 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NUMB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NUMB expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, UCEC, and SKCM are the cancer types where NUMB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.090	0.707	<.001	30	view →
UCEC	DFS	Median	All	0.971	0.605	.002	22	view →
SKCM	OS	Median	III,IV	0.255	0.840	<.001	12	view →
BRCA	OS	Median	All	0.145	0.579	.001	10	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NUMB–KIRP (OS)

Open the KIRP breakdown →