NUMB

Across TCGA pan-cancer cohorts, NUMB RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of NUMB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NUMB RNA is repressed in tumor relative to normal tissue. In most cancer types NUMB is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and COAD are the cancer types where NUMB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUMB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.828	<.001	9	view →
LUSC	Female	All	−0.898	<.001	8	view →
COAD	Female	All	−0.477	<.001	8	view →
HNSC	All	All	+0.429	<.001	8	view →
LUAD	Female	II,III,IV	−0.573	<.001	7	view →
CHOL	All	All	+0.724	.005	4	view →
ESCA	All	All	+0.705	.026	4	view →
READ	All	II,III,IV	−0.412	<.001	4	view →
KIRP	All	II,III,IV	+0.378	.011	4	view →
UCEC	All	All	−0.323	.016	2	view →
PAAD	Male	All	+0.289	.007	2	view →
LIHC	All	All	+0.252	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

NUMB–THCA

Open the THCA breakdown →