NUMB

Across TCGA pan-cancer cohorts, NUMB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUMB data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUMB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NUMB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and COAD are the cancer types where NUMB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	1.000	0.451	.016	15	view →
UCEC	DFS	Median	All	1.000	0.936	.022	8	view →
COAD	DFS	Median	III,IV	1.000	0.841	.041	6	view →
LSCC	DFS	Median	II,III,IV	0.444	0.883	.030	4	view →
LUAD	OS	Median	All	1.000	0.798	.018	3	view →
PDAC	DFS	Median	II,III,IV	0.837	0.624	.022	3	view →
GBM	OS	Quartile	All	0.878	0.997	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUMB–CCRCC (OS)

Open the CCRCC breakdown →