NUMB

Across TCGA patient cohorts, NUMB mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUMB-associated genes across cancer lineages are INPP4B, p62 Lck ligand, and 14-3-3_beta. Each is linked with NUMB in more than 1 cancer types. Because this analysis shows association rather than direction, both NUMB-to-partner and partner-to-NUMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by NUMB-low versus NUMB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUMB→partner) and Y-score (partner→NUMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.227	-2.807	.030	.002	3	2
UCEC	p62 Lck ligand →	+0.271	+1.807	.010	.024	3	2
UCEC	14-3-3_beta →	-0.089	-2.088	.006	.016	3	1
UCEC	eIF4E →	+0.171	+3.598	.012	.001	3	1
UCEC	A-Raf_pS299 →	-0.091	-1.700	.019	.040	3	1
UCEC	ERK2 →	+0.132	+1.807	.035	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

INPP4B by NUMB expression — UCEC

Explore this box plot interactively →