NUMB

Across TCGA cell cohorts, NUMB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,209 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NUMB-associated GO terms across cancer lineages are Protein catabolic process at synapse, Protein catabolic process at postsynapse, and Vacuolar transport. Each is linked with NUMB in more than 17 cancer types. Because this analysis shows association rather than direction, both NUMB-to-partner and partner-to-NUMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein catabolic process at synapse grouped by NUMB-low versus NUMB-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUMB→partner) and Y-score (partner→NUMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Protein catabolic process at synapse →	+0.169	+1.309	.003	.003	3	18
BLOOD_Myeloma	Protein catabolic process at postsynapse →	+0.169	+1.309	.003	.003	3	18
STOMACH	Vacuolar transport →	+0.095	+1.019	.001	<.001	3	15
STOMACH	Endosomal transport →	+0.066	+0.944	.001	<.001	3	14
OVARY	Endosome to lysosome transport →	+0.065	+0.726	<.001	.001	3	13
STOMACH	Cytosolic transport →	+0.076	+0.849	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,209 associations by consensus.

Protein catabolic process at synapse by NUMB expression — BLOOD_Myeloma

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