NUMA1

Across TCGA pan-cancer cohorts, NUMA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUMA1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUMA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUMA1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where NUMA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.574	0.910	.013	15	view →
LUAD	OS	Median	All	1.000	0.767	.004	14	view →
PDAC	OS	Median	IV	0.951	0.381	.006	12	view →
UCEC	OS	Median	II,III,IV	0.629	1.000	.025	8	view →
CCRCC	OS	Tertile	III,IV	0.905	0.522	.018	5	view →
LSCC	DFS	Median	All	0.861	0.715	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUMA1–HNSC (DFS)

Open the HNSC breakdown →