NUMA1

Across TCGA pan-cancer cohorts, NUMA1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NUMA1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where NUMA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NUMA1 is over-expressed in tumor, although a few such as UCEC and KIRP show the opposite, repressed pattern.

LIHC, UCEC, and CHOL are the cancer types where NUMA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUMA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.041	<.001	7	view →
UCEC	All	All	−0.628	<.001	6	view →
CHOL	All	All	+2.035	<.001	5	view →
STAD	Male	II,III,IV	+0.940	.019	2	view →
KIRP	Male	All	−0.589	<.001	2	view →
PRAD	All	All	+0.415	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NUMA1–LIHC

Open the LIHC breakdown →