NUMA1

Across TCGA patient cohorts, NUMA1 mutation is significantly associated with the RNA expression of many other genes, with 4,064 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUMA1-associated genes across cancer lineages are HAUS1, H3P16, and HINT1. Each is linked with NUMA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUMA1-to-partner and partner-to-NUMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS1 grouped by NUMA1-low versus NUMA1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUMA1→partner) and Y-score (partner→NUMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	HAUS1 →	+0.411	+2.355	.006	.003	3	4
STAD	H3P16 →	+1.594	+2.750	<.001	.002	3	4
STAD	HINT1 →	+0.447	+2.509	.001	.008	3	4
STAD	FHL1 →	-1.357	-3.560	.001	.002	3	4
CESC	PHKG1P1 →	+0.039	+4.559	<.001	.006	3	4
COAD	ENO2 →	+0.983	+2.807	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,064 associations by consensus.

HAUS1 by NUMA1 expression — STAD

Explore this box plot interactively →