NUMA1

Across TCGA cell cohorts, NUMA1 mutation is significantly associated with the RNA expression of many other genes, with 465 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUMA1-associated genes across cancer lineages are C10orf120, TNFAIP1, and CALU. Each is linked with NUMA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUMA1-to-partner and partner-to-NUMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf120 grouped by NUMA1-low versus NUMA1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUMA1→partner) and Y-score (partner→NUMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C10orf120 →	+0.012	+3.947	<.001	.004	3	2
LARGE_INTESTINE	TNFAIP1 →	+0.597	+1.409	.002	.005	3	2
BLOOD_Leukemia	CALU →	+0.737	+3.351	.001	.003	3	2
BLOOD_Leukemia	HID1 →	+0.887	+3.115	<.001	.009	3	2
BLOOD_Leukemia	ZCCHC4 →	+0.423	+3.214	.001	.006	3	2
BLOOD_Leukemia	OGFOD1 →	+0.528	+3.120	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 465 associations by consensus.

C10orf120 by NUMA1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →