NUDT6

Across TCGA pan-cancer cohorts, NUDT6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NUDT6 data layer compared with 18 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUDT6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NUDT6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where NUDT6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.802	0.229	<.001	54	view →
LSCC	DFS	Quartile	All	0.521	0.901	.010	18	view →
PDAC	DFS	Quartile	All	0.882	0.411	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NUDT6–CCRCC (OS)

Open the CCRCC breakdown →