NUDT6

Across TCGA pan-cancer cohorts, NUDT6 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NUDT6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NUDT6 RNA is repressed in tumor relative to normal tissue. In most cancer types NUDT6 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where NUDT6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUDT6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.499	<.001	12	view →
THCA	All	II,III,IV	−0.497	<.001	11	view →
KICH	Female	All	−1.169	<.001	10	view →
KIRP	Male	III,IV	−0.700	<.001	9	view →
BRCA	All	All	−0.177	.001	6	view →
CHOL	All	All	−0.544	.003	3	view →
HNSC	Male	All	−0.163	.022	3	view →
UCEC	All	All	−0.366	.012	2	view →
LUSC	Male	III,IV	−0.324	.005	2	view →
LUAD	Female	II,III,IV	−0.234	<.001	2	view →
LIHC	Female	All	−0.334	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NUDT6–KIRC

Open the KIRC breakdown →