NUDT6

Across TCGA patient cohorts, NUDT6 mutation is significantly associated with the RNA expression of many other genes, with 552 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT6-associated genes across cancer lineages are MIR548D2, RNU6-330P, and SNORD113-7. Each is linked with NUDT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT6-to-partner and partner-to-NUDT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548D2 grouped by NUDT6-low versus NUDT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT6→partner) and Y-score (partner→NUDT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR548D2 →	+0.399	+3.235	<.001	.001	3	2
BRCA	RNU6-330P →	+0.794	+9.057	<.001	.003	3	2
BRCA	SNORD113-7 →	+2.424	+8.055	<.001	.007	3	2
BRCA	RNY1P8 →	+0.761	+7.731	<.001	.009	3	2
UCEC	MIR550A1 →	+0.339	+2.599	.001	.003	3	2
UCEC	MIR1225 →	+0.297	+3.027	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 552 associations by consensus.

MIR548D2 by NUDT6 expression — UCEC

Explore this box plot interactively →