NUDT6

Across TCGA patient cohorts, NUDT6 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT6-associated genes across cancer lineages are Ku80, MEK1, and MSH2. Each is linked with NUDT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT6-to-partner and partner-to-NUDT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by NUDT6-low versus NUDT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT6→partner) and Y-score (partner→NUDT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.236	+1.887	.032	.031	3	1
UCEC	MEK1 →	+0.582	+3.700	<.001	.001	3	1
UCEC	MSH2 →	-0.317	-2.973	.003	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.227	+1.887	.018	.031	3	1
UCEC	Myosin-IIa →	+0.221	+1.881	.010	.031	3	1
UCEC	p62 Lck ligand →	+0.441	+2.179	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Ku80 by NUDT6 expression — UCEC

Explore this box plot interactively →