NUDT6

Across TCGA cell cohorts, NUDT6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUDT6-associated genes across cancer lineages are COX6A2, CCER1, and OR10C1. Each is linked with NUDT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT6-to-partner and partner-to-NUDT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by NUDT6-low versus NUDT6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT6→partner) and Y-score (partner→NUDT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX6A2 →	+0.136	+6.022	<.001	.001	3	1
LARGE_INTESTINE	CCER1 →	+0.019	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR10C1 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DEFA3 →	+0.102	+5.415	<.001	.004	3	1
BLOOD_Leukemia	LALBA →	+0.035	+4.922	<.001	.009	3	1
BLOOD_Leukemia	CRYGA →	+0.049	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

COX6A2 by NUDT6 expression — LARGE_INTESTINE

Explore this box plot interactively →