NUDT18

Across TCGA cell cohorts, NUDT18 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUDT18-associated genes across cancer lineages are GUCA2A, MPC1L, and KRTAP7-1. Each is linked with NUDT18 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT18-to-partner and partner-to-NUDT18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by NUDT18-low versus NUDT18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT18→partner) and Y-score (partner→NUDT18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1
BLOOD_Leukemia	MPC1L →	+0.108	+4.409	<.001	.005	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.071	+4.539	<.001	.007	3	1
LARGE_INTESTINE	MS4A4A →	+0.210	+3.678	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.336	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GUCA2A by NUDT18 expression — BLOOD_Leukemia

Explore this box plot interactively →