NUDT16L1

Across TCGA pan-cancer cohorts, NUDT16L1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUDT16L1 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NUDT16L1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUDT16L1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

UCEC, LUAD, and LSCC are the cancer types where NUDT16L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.628	1.000	.013	30	view →
LUAD	OS	Median	All	1.000	0.767	.004	26	view →
LSCC	DFS	Tertile	All	0.811	0.527	.004	11	view →
OV	DFS	Median	All	0.970	0.615	.039	4	view →
CCRCC	DFS	Median	II,III,IV	0.714	0.511	.040	2	view →
GBM	OS	Quartile	All	0.605	0.349	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUDT16L1–UCEC (OS)

Open the UCEC breakdown →