NUDT1

Across TCGA patient cohorts, NUDT1 mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT1-associated genes across cancer lineages are C2orf15, OR6W1P, and SREBF2-AS1. Each is linked with NUDT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT1-to-partner and partner-to-NUDT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf15 grouped by NUDT1-low versus NUDT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT1→partner) and Y-score (partner→NUDT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C2orf15 →	+0.635	+3.202	.007	.009	3	1
UCEC	OR6W1P →	+0.172	+3.151	.001	.001	3	1
UCEC	SREBF2-AS1 →	+0.706	+3.223	<.001	.009	3	1
UCEC	KRTAP23-1 →	+0.288	+3.132	<.001	.003	3	1
UCEC	RNU6-582P →	+0.261	+4.245	<.001	.006	3	1
UCEC	RNU4-58P →	+0.337	+3.548	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

C2orf15 by NUDT1 expression — UCEC

Explore this box plot interactively →