NUCKS1

Across TCGA pan-cancer cohorts, NUCKS1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NUCKS1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NUCKS1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUCKS1 expression acts as an unfavorable survival marker.

STAD and SKCM are the cancer types where NUCKS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	All	0.211	0.709	.015	3	view →
SKCM	OS	Median	II,III,IV	0.258	0.731	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

NUCKS1–STAD (DFS)

Open the STAD breakdown →