NUCKS1

Across TCGA pan-cancer cohorts, NUCKS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUCKS1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUCKS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUCKS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, CCRCC, and OV are the cancer types where NUCKS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.291	1.000	.001	26	view →
CCRCC	DFS	Median	II,III,IV	0.961	0.769	.011	8	view →
OV	DFS	Median	All	0.682	0.923	.047	4	view →
LSCC	DFS	Quartile	All	0.495	0.767	.027	2	view →
GBM	DFS	Quartile	All	0.265	0.419	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NUCKS1–HNSC (DFS)

Open the HNSC breakdown →