NUCKS1

Across TCGA patient cohorts, NUCKS1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,878 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NUCKS1-associated genes across cancer lineages are CLK2, ACBD6, and C1orf56. Each is linked with NUCKS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both NUCKS1-to-partner and partner-to-NUCKS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NUCKS1 versus CLK2 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCKS1→partner) and Y-score (partner→NUCKS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLK2 →	+0.609	+0.601	<.001	<.001	3	7
LSCC	ACBD6 →	+0.493	+0.360	<.001	<.001	3	7
UCEC	C1orf56 →	+0.501	+0.491	<.001	<.001	3	6
HNSC	SMG7 →	+0.608	+0.321	<.001	<.001	3	6
BRCA	DDX59 →	+0.631	+0.711	<.001	<.001	3	6
BRCA	RPRD2 →	+0.737	+0.600	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,878 associations by consensus.

NUCKS1 vs CLK2 — BRCA

Explore this scatter interactively →