NUCKS1

Across TCGA patient cohorts, NUCKS1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUCKS1-associated genes across cancer lineages are NK cells, mv Endothelial cells, and Skeletal muscle. Each is linked with NUCKS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUCKS1-to-partner and partner-to-NUCKS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NK cells grouped by NUCKS1-low versus NUCKS1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCKS1→partner) and Y-score (partner→NUCKS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NK cells →	+0.009	+5.597	<.001	.040	3	1
UCEC	mv Endothelial cells →	-0.021	-3.321	.039	.010	3	1
UCEC	Skeletal muscle →	-0.046	-2.568	.015	.011	3	1
UCEC	Smooth muscle →	+0.124	+3.186	.023	.010	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

NK cells by NUCKS1 expression — STAD

Explore this box plot interactively →