NUCKS1

Across TCGA cell cohorts, NUCKS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,681 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUCKS1-associated GO terms across cancer lineages are Positive regulation of mitotic cytokinesis, Chromosome condensation, and U2-type prespliceosome assembly. Each is linked with NUCKS1 in more than 17 cancer types. Because this analysis shows association rather than direction, both NUCKS1-to-partner and partner-to-NUCKS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cytokinesis grouped by NUCKS1-low versus NUCKS1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCKS1→partner) and Y-score (partner→NUCKS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of mitotic cytokinesis →	+0.183	+1.446	<.001	<.001	3	18
BONE	Chromosome condensation →	+0.191	+1.261	.005	.002	3	18
OESOPHAGUS	U2-type prespliceosome assembly →	+0.113	+1.134	<.001	<.001	3	17
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.152	+1.071	<.001	<.001	3	17
BREAST	Regulation of DNA-templated DNA replication initiation →	+0.125	+1.083	.003	.003	2	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitotic cell cycle →	+0.060	+0.849	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,681 associations by consensus.

Positive regulation of mitotic cytokinesis by NUCKS1 expression — BREAST

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