NUCKS1

Across TCGA cell cohorts, NUCKS1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUCKS1-associated genes across cancer lineages are ACSM6 and CFHR2. Each is linked with NUCKS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUCKS1-to-partner and partner-to-NUCKS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by NUCKS1-low versus NUCKS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCKS1→partner) and Y-score (partner→NUCKS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ACSM6 by NUCKS1 expression — LARGE_INTESTINE

Explore this box plot interactively →