NUCB2

Across TCGA cell cohorts, NUCB2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUCB2-associated genes across cancer lineages are CDX4, CNGA3, and MSGN1. Each is linked with NUCB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUCB2-to-partner and partner-to-NUCB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDX4 grouped by NUCB2-low versus NUCB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCB2→partner) and Y-score (partner→NUCB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDX4 →	+0.009	+3.632	<.001	.003	3	1
LARGE_INTESTINE	CNGA3 →	+0.030	+3.196	.007	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR14K1 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PPP1R42 →	+0.080	+3.781	.009	.003	3	1
LARGE_INTESTINE	ASB18 →	+0.054	+3.453	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CDX4 by NUCB2 expression — LARGE_INTESTINE

Explore this box plot interactively →