NUCB1-AS1

Across TCGA pan-cancer cohorts, NUCB1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NUCB1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NUCB1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NUCB1-AS1 is over-expressed in tumor, although a few such as PAAD and LUAD show the opposite, repressed pattern.

KIRC, BRCA, and KIRP are the cancer types where NUCB1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUCB1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.086	.003	6	view →
BRCA	All	II,III,IV	+0.168	.006	4	view →
KIRP	All	IV	+0.187	.010	3	view →
PAAD	Female	All	−0.220	.047	2	view →
BLCA	All	All	+0.217	.026	2	view →
PRAD	All	All	+0.141	.029	2	view →
HNSC	Male	III,IV	+0.076	.032	2	view →
LIHC	All	All	+0.066	.014	2	view →
READ	All	II,III,IV	+0.422	.036	1	view →
LUAD	Female	II,III,IV	−0.254	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NUCB1-AS1–KIRC

Open the KIRC breakdown →