NUAK2

Across TCGA patient cohorts, NUAK2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,014 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NUAK2-associated genes across cancer lineages are CENPH, CLDN16, and PCDHB14. Each is linked with NUAK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUAK2-to-partner and partner-to-NUAK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NUAK2 versus CENPH in BRCA, with a Pearson correlation of 0.97.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUAK2→partner) and Y-score (partner→NUAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CENPH →	+1.234	+0.445	<.001	.001	3	2
UCEC	CLDN16 →	+2.691	+0.651	.005	.008	3	2
UCEC	PCDHB14 →	-1.395	-0.778	<.001	.007	3	2
UCEC	ZFHX3 →	-0.985	-0.589	.005	.003	3	2
LUAD	FGD6 →	-0.983	-0.448	.003	.008	3	2
UCEC	MAML3 →	-1.218	-0.661	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,014 associations by consensus.

NUAK2 vs CENPH — BRCA

Explore this scatter interactively →