NUAK2

Across TCGA pan-cancer cohorts, NUAK2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NUAK2 data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NUAK2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NUAK2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and KIRC show a favorable association.

UVM, UCEC, and LGG are the cancer types where NUAK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.423	0.807	<.001	72	view →
UCEC	OS	Tertile	All	0.544	0.821	<.001	68	view →
LGG	OS	Median	All	0.338	0.565	<.001	54	view →
PAAD	OS	Quartile	All	0.670	0.284	<.001	34	view →
KIRC	DFS	Quartile	II,III,IV	0.694	0.360	.010	34	view →
SKCM	DFS	Quartile	IV	0.590	0.138	.004	29	view →
THYM	DFS	Tertile	All	0.793	0.990	<.001	28	view →
HNSC	OS	Median	IV	0.762	0.505	.005	26	view →
LAML	DFS	Tertile	All	0.413	0.744	.011	24	view →
THCA	DFS	Median	All	0.866	0.948	.009	23	view →
MESO	OS	Median	All	0.468	0.631	.026	13	view →
READ	DFS	Tertile	II,III,IV	0.544	0.810	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NUAK2–UVM (OS)

Open the UVM breakdown →