NUAK2

Across TCGA patient cohorts, NUAK2 mutation is significantly associated with the RNA expression of many other genes, with 3,924 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUAK2-associated genes across cancer lineages are CARS1P1, RNA5SP410, and MIR4510. Each is linked with NUAK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUAK2-to-partner and partner-to-NUAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARS1P1 grouped by NUAK2-low versus NUAK2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUAK2→partner) and Y-score (partner→NUAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CARS1P1 →	+0.064	+4.392	<.001	.006	3	3
LUSC	RNA5SP410 →	+0.593	+4.309	<.001	.007	3	3
CESC	MIR4510 →	+0.195	+4.342	<.001	.007	3	2
SKCM	CTBP2P9 →	+0.015	+2.965	.001	.008	3	2
SKCM	LINC00294 →	+0.518	+2.813	.005	.001	3	2
COAD	TRAJ30 →	+1.021	+3.496	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,924 associations by consensus.

CARS1P1 by NUAK2 expression — COAD

Explore this box plot interactively →