NUAK2

Across TCGA cell cohorts, NUAK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,858 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NUAK2-associated GO terms across cancer lineages are Platelet aggregation, Positive regulation of hippo signaling, and Homotypic cell-cell adhesion. Each is linked with NUAK2 in more than 10 cancer types. Because this analysis shows association rather than direction, both NUAK2-to-partner and partner-to-NUAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Platelet aggregation grouped by NUAK2-low versus NUAK2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUAK2→partner) and Y-score (partner→NUAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Platelet aggregation →	+0.109	+1.367	.001	<.001	3	11
BLOOD_Lymphoma	Positive regulation of hippo signaling →	+0.173	+1.694	<.001	<.001	3	9
BONE	Homotypic cell-cell adhesion →	+0.129	+1.199	<.001	<.001	3	9
OVARY	Negative regulation of complement-dependent cytotoxicity →	+0.166	+1.436	.002	.001	2	9
PANCREAS	Non-canonical NF-kappaB signal transduction →	+0.098	+1.318	.005	.008	3	8
BONE	Protein targeting to vacuole involved in autophagy →	+0.170	+0.971	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,858 associations by consensus.

Platelet aggregation by NUAK2 expression — LUNG_SCLC

Explore this box plot interactively →