NUAK2

Across TCGA cell cohorts, NUAK2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible NUAK2-associated genes across cancer lineages are BMP10, C4orf50, and TRIM77. Each is linked with NUAK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUAK2-to-partner and partner-to-NUAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP10 grouped by NUAK2-low versus NUAK2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUAK2→partner) and Y-score (partner→NUAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BMP10 →	+0.016	+3.628	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.030	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
SKIN	TINAG →	+0.171	+3.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

BMP10 by NUAK2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →