NTSR2

Across TCGA cell cohorts, NTSR2 mutation is significantly associated with the mutation status of many other genes, with 4,698 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NTSR2-associated genes across cancer lineages are LPA, MMEL1, and SLC9C1. Each is linked with NTSR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NTSR2-to-partner and partner-to-NTSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LPA grouped by NTSR2-low versus NTSR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTSR2→partner) and Y-score (partner→NTSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LPA →	+1.693	+2.287	.005	.005	1	4
LUNG_NSCLC_LUAD	MMEL1 →	+3.662	+3.000	.007	.007	1	3
BLOOD_Leukemia	SLC9C1 →	+3.285	+3.662	.004	.004	1	3
LARGE_INTESTINE	PLEKHG5 →	+3.056	+2.895	<.001	<.001	1	3
LARGE_INTESTINE	PIK3CG →	+2.248	+2.445	.003	.003	1	3
LARGE_INTESTINE	MTR →	+2.149	+3.000	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,698 associations by consensus.

LPA by NTSR2 expression — LARGE_INTESTINE

Explore this box plot interactively →