NTSR1

Across TCGA patient cohorts, NTSR1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTSR1-associated genes across cancer lineages are JNK2, PCNA, and PEA-15_pS116. Each is linked with NTSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTSR1-to-partner and partner-to-NTSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by NTSR1-low versus NTSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTSR1→partner) and Y-score (partner→NTSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.424	+2.817	<.001	.036	3	1
UCEC	PCNA →	+0.340	+3.000	.006	.037	3	1
UCEC	PEA-15_pS116 →	+0.578	+3.000	.004	.037	3	1
UCEC	BRD4 →	+0.447	+3.007	.003	.019	3	1
UCEC	GATA6 →	-0.225	-2.992	.011	.036	2	1
UCEC	SCD →	-0.144	-2.986	.023	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK2 by NTSR1 expression — UCEC

Explore this box plot interactively →